Metabolic Preservation Strategies: A Clinical Framework for Resistance Training and Nutrient Timing in GLP-1 Therapy

Emerging data indicate that 20% to 50% of total weight loss during GLP-1 RA therapy may consist of lean mass, with some cohorts showing muscle loss as high as 60%. This reduction in skeletal muscle integrity presents a significant risk for sarcopenic obesity, metabolic rate depression, and decreased functional independence.